【摘要】 合成了一系列新型Ｏ－糖基－甲氧甲酰基膦酰胺酯，并对Ｏ－糖基亚磷酰胺酯与氯甲酸甲酯的Ａｒｂｕｚｏｖ反应及其它有关反应进行了讨论。产物的结构经^１ＨＮＭＲ、^３１ＰＮＭＲ、ＩＲ及元素分析确定。初步的生物活性测定结果表明，化合物３_ｅ对人肝癌Ｂｅｌ－７４０２细胞和人白血病ＨＬ－６０细胞有一定的抑制作用。化合物３ａ对烟草花叶病毒有一定的抑制活性．更多还原

【Abstract】 A series of novel O-saccharidyl-methoxyformylphosphosphonamidates were synthesized,and Arbuzov reaetions of O-saccharidylphosphoramidites with methyl chloroformate and other related reactions were disussed.The structures of the products were determined by￣1H NMR,￣(31)P NMR, IR and elemental analyses. The results of preliminary biological tests showed that compound 3_c possessed some inhibitory activities against Leukaemia HL-60 cells and liver cancer Bel-7402 cells in vitro,compound 3_a has some antivirus activity against tobacco mosaic virus(TMV).更多还原