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β－阻断剂及其代谢产物的气相色谱分析研究（Ⅲ）──用固相提取及GC／MS法分析大鼠尿中5种β－阻断剂及其代谢物

Studies on the Analysis of β-blockers and Their Metabolites in Urine by Gas Chromatography (Ⅲ)──Analysis of Five β-Blockers and Their Metabolites in Rats’ Urine by Solid-phase Extraction and GC/MS

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【Author】 XU You-Xuan;SHEN Li; WANG Shan; WU Yun; ZHANG Chang-Jiu (China Doping Control Centre,National Research Institute of Sports Medicine, Beijing, 100029 )

【机构】国家体育运动委员会运动医学研究所兴奋剂检测中心；

【摘要】用Ｓｅｐ－ｐａｋ柱固相提取、酶解、液－液萃取、衍生化及ＧＣ／ＭＳ分析等步骤，研究了大鼠尿中５种β－阻断剂，初步推断了多种代谢物的结构，建立了此类药物的分析方法。更多还原

【Abstract】 A procedure for detecting β-blockers was establ ished.Five β-blockers were administrated to rats. The rats’ metabolic urine tqamples were hydrolysed with β-glucuronidase,extracted by Sep-Pak C₁₈ columns,and analyzed by GC/MS.Their metabolites were identified by mass spectra and metabolic theories.The recoveries of the drugs were all over 75%.The hydrolysed metliods were compared and the mass fragmentation mechanism was discussed.更多还原

【关键词】 β－阻断剂；代谢物； GC／MS；
【Key words】 blocker； Metabolite； GC/MS；

【文献出处】高等学校化学学报 ,CHEMICAL RESEARCH IN CHINESE UNIVERSITIES , 编辑部邮箱 ,1995年03期

【分类号】O657.71
【下载频次】55

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