【摘要】 本文以抗免疫抑制酸性蛋白（ＩＡＰ）单克隆抗体、ＡＢＣ免疫酶标组化技术，对５５例头颈部恶性肿瘤和２４例头颈部良性病变组织中ＩＡＰ进行了定位研究。结果表明，良性病变的ＩＡＰ表达均为阴性，恶性肿瘤的阳性表达率为９１．６％，其中高分化癌（Ⅰ、Ⅱ级）、低分化癌（Ⅲ级）、未分化癌（Ⅳ级）的阳性率分别为６６．７％、９０．０％、１００．０％和１００．０％。ＩＡＰ表达阳性率的高低及表达程度的强弱与头颈癌的分化程度有密切关系。ＩＡＰ可望成为一种有用的肿瘤标记物。更多还原

【Abstract】 Abstract Immunohistochemical investigations were carried out to determine the distribution and signi-ficance of IAP in the tissue of malignant tumors of the head and neck by using anti-IAP mono-clonal antibody and ABC immunoperoxidase histochemical assay.55 specimens of malignant tu-mors and 24 of benign lesions of the head and neck were inclusded in this study,The results re-vealed that IAP was negative in specimens of benign lesions while the positive rate was as high as94.6% in malignant tumors of the head and neck.The positive rates in head and neck squamous cell carcinoma of Grade Ⅰ,Ⅲ,mand Ⅳ according to Broder were 66.7%,90.0%,100.0% and 1 00.0% respectively.The data suggest that head and neck carcinoma cells can produce IAP and the positive rate of IAP rises with the development of the histopathological grade of carcino-ma. IAP may be an valuable tumor marker in early diagnosis,evaluation of treatment, prognosis,recurrence and staging of the head and neck carcinoma.更多还原