【摘要】 以饮用高氟水的方法制造了雄性大鼠慢性氟中毒模型。对脑干中缝背核5—羟色胺(5—HT)能神经元进行了免疫细胞化学定性、定量研究,结果显示,慢性氟中毒大鼠中缝背核5—HT能神经元略少,部分胞体缩小或肿大。胞质内5—HT阳性反应颗粒减少且界限不清。显微图像分析仪检测上述神经元内5—HT阳性反应颗粒明显减少。本研究揭示,高氟摄入对中枢5—HT能神经元有直接损害,对5—HT的产生有抑制作用。更多还原

【Abstract】 The male rats model of chronic fluorosis was established with administration of large dose fluoride in drinking water. The qualitative and quantitative analysis of serotonin (5-HT)neurons in nucleus raphe dorsalis (NRD) with immunocytochemical technique was done. The results showed that the number of 5-HT positive neurons decreased in fluorosis group with the declened 5-HT positive particles in cytoplasm. Some 5-HT like neuron body becomes dystrophy or swelling. With cell image analysis,the 5-HT contents,in the 5-HT neurons,decreased significantly in fluorosis group,which suggests that the administration of larger does of fluoride damage the central serotonin neurons directly and may inhibit the producing of 5-HT.更多还原