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凝血和纤溶系统多参数测定在急性心肌梗塞溶栓治疗中的探讨

CHANGES IN FIBRINOLYTIC ACTIVITY IN PATIENTS WITH ACUTE MYOCARDAL INFARCTION DURING THROMBOLYTIC THERAPY AND THEIR CLINICAL SIGNIFICANCE

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【作者】 于贵杰韩红刘金荣王秀梅刘宁张朝红

【Author】 Department of Clinical Laboratory,People’s Hosptial Yu Guijie,et al

【机构】 北京医科大学人民医院检验科

【摘要】 应用免疫比浊和发色底物法测定15例AMI患者血浆中的AT-Ⅲ、PLG、α-APL、PT、PA、FIB。结果显示:AMI患者AT-Ⅲ为86.40±30.40与对照组109.80±14.80相比存在显著差异(P<0.01);溶栓前、后PT、PA、FJB、PLG、α2-APL有极显著性差异(P<0.001)。提示上述指标可作为AMI辅助诊断、溶栓治疗监护和预防出血的指标。

【Abstract】 ntithrombin Ⅲ(AT-Ⅲ),Plasminogen (PL),α2-antiplasmin(α2-APL),fibrinogen(FIB).prothrombin time(PT)and prothrombin activity(PA) were measured before and after thrombolytic treatment in 15 patients suffer-ing from their early attack of acute myocardial infaretion(AMI).The result suggested that AT-Ⅲ activity of AMI decreased(P<0.05) compared to control,which indicated the existence of an abnormal procoagulant state.Compared to pretreatment values ,PLG,α2-APL,PT and pro-thrombin activity decreased remarkably (P<0.01~P<0.001),the largest reduction in fibrinogen observed .No patient had clinical evidence of reinfarction and hemorrhage.

  • 【文献出处】 北京医科大学学报 ,Journal of Beijing Medical University , 编辑部邮箱 ,1995年06期
  • 【分类号】R542.22
  • 【被引频次】1
  • 【下载频次】11
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