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唐古特酒对D-半乳糖胺中毒小鼠肝脏组织化学与超微结构的作用
THE ULTRASTRUCTURAL AND HISTOCHEMICAL OBSERVATIONS ABOUT THE EFFECT OF “TANGUTICUM”ON HEPATIC LESION OF MOUSE INDUCED BY GALACTOSAMINE
【摘要】 以D-半乳糖胺(500mg·kg-1)给予小鼠腹腔注射24~48h后,导致实验性肝病变,观察可见肝细胞组织酶反应减弱,超微结构严重受损。如先给动物胃饲12d唐古特酒,再以半乳糖胺中毒,则动物肝细胞组织酶反应与超微结构仍正常。提示唐古特酒对肝细胞具保护作用。
【Abstract】 The experimental hepatic lesion of mouse were induced by intraperitoneal injection of D-galactosamine (500mg·kg ̄(-1)).After 24 ̄48h, the reaction of RNA, DNA and succinic dehydrogenase (SDHase) of the cells were decreased and the ultrastructure were damaged.While administered with “Tanguticum” by gastrogavage for 12 d before the injection of D-galactosamine,the liver cells could be prevented by the effect of“Tanguticum”,and the liver cells is still normal in histochemical and ultrastructural observations.This suggested that the protection of “Tanguticum”prevents mouse liver from the galactosamine intoxication.
【Key words】 D-galactosamine; rhubarb; “Tanguticum”; liver cell; succinic dehydrogenase;
- 【文献出处】 北京师范大学学报(自然科学版) ,JOURNAL OF BEIJING NORMAL UNIVERSITY , 编辑部邮箱 ,1995年02期
- 【分类号】Q956
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