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恶性淋巴瘤的核仁组成区相关嗜银蛋白的定量研究

A QUANTITATIVE STUDY OF NUCLEOLAR ORGANIZER REGIONS IN LYMPHOMAS

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【作者】 卢洁; 谷仁凯; 刘毅; 徐贤秋; 董增义; 周容;

【Author】 Lu Jie;Gu Renkai;Liu Yi;et al(Department of Pediatric)

【机构】 青岛纺织工人疗养院;

【摘要】 对55例淋巴结石腊包埋切片进行了核仁组成区相关嗜银蛋白(AgNORs)定量研究。结果表明:31例恶性淋巴瘤Ag-NORs计数为6.62±3.02,24例良性淋巴结病变为1.69±0.47,两组比较有极显著差异(P<0.01);在非何杰金淋巴瘤(NHL)中,低度恶性组Ag-NORs计数为3.79±1.46,而中、高度恶性组为8.28±2.58,两组间亦有极显著差异(P<0.01);何杰金病(HD)与NHL间无显著差异(P>0.05)。结果提示,Ag-NORs技术简便、快速、实用,对淋巴结良恶性病变的鉴别及恶性淋巴瘤的病理分级,可提供有价值的形态学资料。

【Abstract】 Using silver colloid technique, nucleolar organizer region-associated argyrophilic proteins(Ag-NORs)were studied quantitatively in the biopsy of lymph nodes from 55patients. The results showed that the Ag-NORs count was 6.62±3.02 in 31 lymph nodes with malignant lymphoma and 1.69±0.47 in 24 lymph nodes with benign changes, the difference being significant(P<0.01). In non-Hodgkin’s lymphoma, the Ag-NORs count was significantly higher in cases of low-degree differentiation than in cases of high-degree differentiation(P< 0.01). This technique may be valuable in the study of the differential diagnosis between the benign and malignant lmmph nodes and in the grading of non-Hodgkin’s lymphoma.

  • 【分类号】R446.41
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