【摘要】 持续电刺激膈神经３０～４０ｍｉｎ复制膈肌疲劳（ＤｉＦ），分别测量伤前及伤后３０ｍｉｎ、６０ｍｉｎ、９０ｍｉｎ、１２０ｍｉｎ的跨膈压（Ｐｄｉ）及膈肌诱发电位（ＤＥＰ）变化，实验发现：复制ＤｉＦ后，Ｐｄｉ减少４４．２％；ＤＥＰ幅度降低４８．０３％；ＤＥＰ潜伏期延长２３．７％．上述变化可被静脉注射牛磺酸１００ｍｇ／ｋｇ所对抗．结果表明：ＤＥＰ可以作为评价膈肌疲劳的一项指标；牛磺酸对电刺激致伤膈肌有保护作用．更多还原

【Abstract】 Electric stimulation of phrenic nerve were performed experimentally for 30～40minto induce diaphragmatic fatigue on rabbits anesthetized with urethan. The transdiaphragmaticpressure(Pdi) and diaphragm evoked potential(DEP) were measured before and 30min,60min,90min and 120min after stimulation. Pdi and the amplitude of DEP were obviously decreased, thelatency of DEP delayed 30min after injury. These change can be inhibited by the adminstration of100mg/kg of taurine. The results indicate that the diaphramatic fatigue can evaluated by DEP andthat the taurine can protect significantly against diaphragmatic fatigue from the phrenic nervestimulation.更多还原