【摘要】 使用长春地辛（ＶＤＳ）和长春碱（ＶＬＢ）治疗恶性肿瘤５６例。结果ＶＤＳ单药有效率为２２．７％，ＶＤＳ联合组有效率４２．１％，ＶＬＢ联合组有效率３５．７％，其中ＶＤＳ＋顺铂（ＤＤＰ）治疗非小细胞肺癌有效率达５０％，稍高于国外相同方案的结果，ＶＬＢ＋ＤＤＰ则为３７．５％。ＶＤＳ和ＶＬＢ的主要毒性为骨髓抑制，白细胞下降（Ⅰ＋Ⅱ＋Ⅲ＋Ⅳ）分别为７３．３％和７４．９％，外周神经毒性轻，所有毒性可以耐受。更多还原

【Abstract】 From November 1993 to July 1994, 56 evaluable patients treatedwith VDS or VLB-containing chemotherapy regimens were analysed. All were diagnosedby pathilogy or cytology. They all had a measurable mass, one of the 56 patients wasin stageⅡ, 18 in stage Ⅲ, and 38 in stage Ⅳ. VDS alone treated case, VDS-Containingor VLB-containing regimen treated cases were 23, 19 and 14, respectively. As a result, the response rates of VDS-alone, VDS combination regimen and VLBcombination regimen were 22.71%, 42.18%, and 35.7%, respectively. Response rate ofpatients with non-small cell lung cancer(NSCLC) treated with VDS+DDP was 50 %. While the response rate of VLB+DDP regimen (contrast group) was only 37.5%.The main toxicty of VDS+DDP regimen observed was myelosuppression, with 73.3%of the patients have leucopenia. Peripheral neurotoxicity was mild, all toxicty was welltolerated.In conclusion,VDS has better activity over VLB against NSCLC and VDS+DDPregimen can be recommended as the treatment of choise in NSCLC更多还原