【摘要】 贝叶多孔菌（ｐｏｌｙｐｏｒｕｓｆｒｏｎｄｏｓｕｓ）是属于担子茵亚门多孔菌属的食用菌。用改良的Ａｍｅｓ试验和微核试验对贝叶多孔菌水相提取液的抑诱变作用作了测试。结果表明，该液对黄曲霉毒素诱导的ＴＡ９８回复突变和对环磷酰胺诱发的小鼠骨髓微核均有一定的抑制作用，且有剂量一效应关系。但Ａｍｅｓ试验中还观察到贝叶多孔菌提取液本身也有一定的诱变性，故对该菌的肿瘤化学预防作用还应作进一步探讨。更多还原

【Abstract】 Polyporus frondosus(Grifola frondosa)is an edible mushroom. It was reportedthat grifolan obtained from the bodies of the mushroom exhibited antitumor activity.Theaqueous extract of Polyporus frondosus was tested with Ames test and micronucleus test forits anti-mutagenic effect,The results exhibited that Polyporus frondosus had certain in-hibitory effects on mutagenic activity to TA98 induced by aflatoxin Bl and micro-nucleus in-duction by cyclophosphamide in marrow cell of mice. Dose-response relationships were no-ticed.But the results also showed that Polyporus frondosus extract itself had weak muta-genicity in Ames test and had a toxicity on reducing body weight of test animals in micronu-cleus test.The results suggested that further research is needed to be done in evaluating theeffect of Polyporus frondosus aqueous extract.更多还原