【摘要】 用黄蜀葵花提取物——甲花素治疗30例原发性肾小球疾病,口服甲花素4～5g/d,2个月为1疗程,治疗前24h 尿蛋白定量平均为2.443g,治疗后降至平均1.126g(P<0.001).浮肿消退或改善,未发现该药对肝、肾功能和血常规有不良影响。4种动物炎症模型的抗炎实验表明该药抗炎作用显著、确切,其作用机制与降低毛细血管通透性。减少炎性渗出有关。更多还原

【Abstract】 It was demonstrated in animal experiment that Jiahuasu(JHS).extract ofAbelmoschus manihot(黄蜀葵花). could significantly inhibit the acetic acid-induced permeability elevating of the abdominal capillaries and the histamin-induced permeability enhancing of the skin capillaries,as well as the xytol-induced edema of the mice’s auricles and the histamine-induced edema of the rats’ paws.30 patients with the primary glomerulopathy were treated with oral JHS for 2 months.The average amount of urinary protein of the patients was 2.443g before treatment and 1.126g after treatment(P<0.001).Accordingly.the edema in the patients was relieved or improved.The mechanism might be relevant with reducing the permeability of the capillaries and the inflammatory exudation.No side-effects of the drug on liver,renal function and blood routine has been found.更多还原