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复方三姐妹片治疗慢性乙型肝炎及其携带者的临床疗效及实验研究
Clinical Effects and Experimental Study on Treatment of Chronic Hepatitis B and Asymptomatic Carriers with Composita Rabdosia ternifold
【摘要】 用复方三姐妹片治疗慢性乙型肝炎和乙肝病毒携带者308例,总有效率为72.4%。HBsAg 转阴率32.8%;滴度下降率39.6%,HBeAg 转阴率58.6%,疗效优于对照组(P<0.01)。动物实验表明,本药可保护小白鼠由 CCl4引起的肝损伤,降低血清 ALT 的活力,可增强细胞免疫,调节体液免疫功能,以上与临床研究结果一致。
【Abstract】 The Composita Rabdosia ternifold(CRT)has been used in treating 308 chronic hepatitis B patients and asymptomatic carriers.After 3~6 months’ treatment,the total effective rate reached 72.4%:the percentage of sero nagative conversion for HBsAg was 32.8% and that for HBeAg was 58.6%.The curative effect in the treated group was better than that of control group(P<0.01).It was shown in the animal experiments that CRT could protect the albino rats from CCl4 injury of liver,it could lower the activity of alanine transaminase (ALT).P<0.01.and enhance the nonspecific immunity and specific humoral and cellular immune function of the immunosuppressed albino rats Hence.a conclusion could be drawn that CRT has such effects as liver protecting,detoxifying,improving hepatic microcirculation,promoting the renovation of hepatic cells,enhancing cellular immunity and adjusting humoral immune function:they were in accordance with clinical curative effects. CRT is an effective medicine for hepatitis B virus infection with low toxicity.
【Key words】 Composita Rabdosia ternifold; chronic hepatitis B; asymptomatic carrier; immune function;
- 【文献出处】 中国中西医结合杂志 ,Chinese Journal of Integrated Traditional and Western Medicine , 编辑部邮箱 ,1994年S1期
- 【分类号】R259
- 【被引频次】9
- 【下载频次】98