【摘要】 应用ＡＢＣ法对４２例乳腺癌、４０例乳腺良性病变新鲜冰冻组织进行了Ｃ－ｅｒｂＢ－２基因蛋白表达的研究，比较了Ｃ－ｅｒｂＢ－２、雌激素受体（ＥＲ）、孕激素受体（ＰｇＲ）、癌胚抗原（ＣＥＡ）在乳腺癌组织中的表达。结果：乳腺癌中２６例（６１．９％）有Ｃ－ｅｒｂＢ－２基因表达，强阳性表达８例（１９．０％），良性乳腺病变也有表达；淋巴结转移多见于Ｃ－ｅｒｂＢ－２阳性、ＥＲ阴性，ＣＥＡ阴性病例；随着Ｃ－ｅｒｂＢ－２表达程度增加（－→＋→＋＋），淋巴结转移阳性率增加，临床分期为Ｉ期的患者数减少，ＩＩ、ＩＩＩ期增多，ＥＲ、ＰｇＲ受体水平下降。提示，Ｃ－ｅｒｂＢ－２基因蛋白表达与预后有关，表达强度越高，预后越差。更多还原

【Abstract】 By using ABC method and frozen section of fresh breast lesion tissue, 26/42(61.9%)cases with breast cancer showed a positive expression of C-erbB-2 oncogene product, while 40 cases with benign breast lesions gave a positive rate of 47.5% (19/40). Reactivities of estrogen receptor(ER), progesterone receptor(PgR) and carcinoembryonic antigen (CEA) were more frequently seen in benign lesions (P<0. 05).Cases with lymphnode metastasis often had a positive C-erbB-2 and negative ER and CEA; increase of C-erbB-2 expression often accompanied by the increase of lymphnode metastatic rate. The result indicates that the expression of C-erbB-2 is related to prognosis, a strong expression means bad prognosis.更多还原