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增殖细胞核抗原(PCNA)与胃癌预后关系的免疫组化研究

IMMUNOHISTOCHEMICAL STUDY ON RELATIONSHIPBETWEEN PCNA AND PROGNOSISOF GASTRIC CARCINOMA

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【作者】 薛玲②周慕珩吴惠茜

【Author】 Xue Ling; Zhou Muheng; Wu Huixi (Department of Pathology , Sun Yat-Sen University of Medical Sciences , Guangzhou , 510089)

【机构】 中山医科大学病理学教研室

【摘要】 应用SLAB免疫酶标法在石蜡切片上半定量分析增殖细胞核抗原(PCNA)的表达与73例胃癌患者预后的关系,探讨其临床应用价值。结果表明,以PCNA阳性细胞50%为界线,阳性率>50%者术后生存期较短,5年生存率较低,而淋巴结转移率则较高。提示PCNA检测可作为胃癌预后判断的良好指征。

【Abstract】 xpression of proliferating cell nuclear antigen (PCNA ) in 73 cases of gastric carcinoma and its relationship to prognosis were semiquantitatively analysed by SLAB immunohis- tochemical method , and its clinical application was explored. The results showed that the . patients with > 50% PCNA positive rate correlated to a decreased survival , but higher rate of lymph node metastasis than that with < 50% positive rate. Our data suggested that PC- NA can be regarded as a significant prognostic indicator in gastric carcinoma.

【基金】 本校科研基金
  • 【文献出处】 中山医科大学学报 ,ACADEMIC JOURNAL OF SUN YAT-SEN UNIVERSITY OF MEDICAL SCIENCES , 编辑部邮箱 ,1994年04期
  • 【分类号】R735.203
  • 【被引频次】3
  • 【下载频次】32
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