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增殖细胞核抗原(PCNA)与胃癌预后关系的免疫组化研究
IMMUNOHISTOCHEMICAL STUDY ON RELATIONSHIPBETWEEN PCNA AND PROGNOSISOF GASTRIC CARCINOMA
【摘要】 应用SLAB免疫酶标法在石蜡切片上半定量分析增殖细胞核抗原(PCNA)的表达与73例胃癌患者预后的关系,探讨其临床应用价值。结果表明,以PCNA阳性细胞50%为界线,阳性率>50%者术后生存期较短,5年生存率较低,而淋巴结转移率则较高。提示PCNA检测可作为胃癌预后判断的良好指征。
【Abstract】 xpression of proliferating cell nuclear antigen (PCNA ) in 73 cases of gastric carcinoma and its relationship to prognosis were semiquantitatively analysed by SLAB immunohis- tochemical method , and its clinical application was explored. The results showed that the . patients with > 50% PCNA positive rate correlated to a decreased survival , but higher rate of lymph node metastasis than that with < 50% positive rate. Our data suggested that PC- NA can be regarded as a significant prognostic indicator in gastric carcinoma.
【关键词】 增殖细胞核抗原;
胃肿瘤;
预后;
【Key words】 proliferating cell nuclear antigen; stomach neoplasm; prognosis;
【Key words】 proliferating cell nuclear antigen; stomach neoplasm; prognosis;
【基金】 本校科研基金
- 【文献出处】 中山医科大学学报 ,ACADEMIC JOURNAL OF SUN YAT-SEN UNIVERSITY OF MEDICAL SCIENCES , 编辑部邮箱 ,1994年04期
- 【分类号】R735.203
- 【被引频次】3
- 【下载频次】32