【摘要】 作者从单核、淋巴因子的角度探讨了Ｔａｍｍ－Ｈｏｒｓｆａｌｌ蛋白（ＴＨＰ）与免疫系统的关系，以及ＴＨＰ通过自身免疫反应诱发肾小管间质性肾炎（ＴＩＮ）的机制。系列研究的结果提示，在生理状态下。ＴＨＰ可能参于了肾脏对某些细胞因子，诸如白细胞介素１、白细胞介素２和肿瘤坏死因子的清除与代谢。当某些病理状态致ＴＨＰ直接进入肾间质时，则可能通过激发细胞免疫反应导致ＴＩＮ。单核／巨噬细胞及其分泌的某些单核因子是介导这类ＴＩＮ组织炎症和纤维化的关键因素。这一结论不仅有助于进一步阐明ＴＨＰ的病理生理作用。同时也可能给某些ＴＩＮ的治疗以新的启示。更多还原

【Abstract】 he relationship between Tamm-Horsfall protein (THP ) and cytokines and the immuno- logical mechanism was studied , by which THP triggers tubulointerstitial nephritis (TIN ). The results showed that THP might play physiologically an important role in the regulation of intrarenal bioactivity of many potent cytokines , including IL-1 , IL-2 and TNF. In some disease states , however , THP could deposit in the extra-tubular interstitium through leak- age of urine from rupture of obstructed or damaged tubules , and might be able to activate cell-mediated immunity to induce TIN. Monocytes/macrophages and monokines produced by these cells played a key role in the tissue injury in this type of TIN and probably contributed to tubulointerstitial fibrosis. Besides their significance in the understanding of the patho- physiologic effects of THP , the results may also provide a new hint for the treatment of some types of TIN.更多还原