【摘要】 本研究用ＥＬＩＳＡ法同步、动态地检测了２８５例ＭＧ患者血清乙酰胆碱受体抗体（ＡｃｈＲａｂ）、突触前膜抗体（ＰｓＭａｂ）和胸腺瘤相关抗体（ＣＡＥａｂ）的变化。实验结果表明，ＭＧ患者体内增高的ＡｃｈＲａｂ是ＭＧ发病的主要体液因素。部分血清ＡｃｈＲａｂ阴性ＭＧ患者（１７．５％）的发病，可能与血清ＰｓＭａｂ异常有关。另一部分血清ＡｃｈＲａｂ和ＰｓＭａｂ均异常的ＭＧ患者（１２．６％），则可能同时存在骨骼肌神经肌接头突触前和突触后的损害。血清ＣＡＥａｂ测定在辅助诊断胸腺瘤方面具有高度的灵敏度和特异性，可作为临床早期诊断胸腺瘤的过筛检查。更多还原

【Abstract】 In this report,acetylcholine receptor antibody (AchRab),pre-synaptic membrane antibody(PsMab),and thymomaassociated antibody or citric acid extract antibody(CAEab) in sera of 285 patients with myasthenia gravis (MG) were dynamically detected with ELISA.The results showed that the increased seral AchRab might be a major factor in pathogenesis of MG.For the kind of seronegative MG patients (17.5%),seral PsMab may play an important role in etiology and pathogenesis of MG.There may be both post-synaptic and presynaptic damages in the patients whose seral AchRab and PsMab titers are increased. The detection of serum CAEab with ELISA possesses high sensitivity and specificity in discover ing thymoma. This serological assay may be used as a screen test for diagnosing thymoma early in neurological bedside.更多还原