【摘要】 本文报道１００例原发全身性癫痫家系的遗传流行病学研究结果。先证者一级亲属患病率为６．８６％，二级亲属为１．０３％；分别是对照组一级亲属的１３．８３倍和２．０８倍。原发全身性癫痫的遗传度为：一级亲属０．７５２１±０．０６７８，二级亲属０．３５９２±０．０７４６；加权平均０．５７４３±０．０５０２。说明遗传因素起重要作用。发病年龄影响因素分析表明：原发全身性癫痫有一定年龄依从性。ＥＥＧ家系分析显示，该型癫痫一级亲属癫痫样放电明显高于对照组一级亲属，提示癫痫样放电的遗传倾向。更多还原

【Abstract】 The result of genetic epidemiological study in pedigrees with primary generalized epilepsy (PGE)is reported in this paper. The prevalence rates of proband’s first and second degree relatives were 6.86% and 1.03%, respectively which were 13.83 and 2.08 times as high as that of the control’s first relatives. The heritabilities of PGE in the first and second relatives were estimated 0.7521±0.0678 and 0.3592 ±0.0746 respectively. The weighted average of the heritability was estimated at 0.5734 ±0.0502. It suggests that the genetic factor playS an important role in PGE. The analysis on the onset age shows that the prevalence rate of PGE has a marked relation to age. EEG of the pedigrees with PGE were studied. The result showed that the rates of epileptiform discharges in PGE first relatives were markedly higher than that in the control’s first relatives. It suggests that epileptiform discharges may be inherited.更多还原