【摘要】 静脉注射ＢａＩｂ／ｃ小鼠（Ｈ－２￣ｄ）脾细胞和骨髓细胞，４８小时后，腹腔注射环磷酰胺和抗胸腺细胞血清，可诱导Ｂ６小鼠（Ｈ－２￣ｂ）对ＢａＩｂ／ｃ小鼠皮肤移植的长期耐受（＞８０天）．耐受Ｂ６小鼠可正常排斥无关品系ＣＢＡ／Ｊ小鼠（Ｈ－２￣ｋ）的皮肤，显示了耐受的特异性。上述诱导方案可导致受体小鼠脾细胞对ＣｏｎＡ、ＬＰＳ诱导的增植反应的抑制，但这种全身性免疫抑制可在短期内恢复，而供体特异性的同种异型反应，如ＭＬＲ和ＤＴＨ则不能恢复。更多还原

【Abstract】 When C57BL/6(B6)mice (H-2￣b)received an intravenous injection of allogeneic spleen cellsand bone marrow cells from Balb/c mice(H-2￣d),followed by an intraperitoneal injection of cy-clophosphamide and antithymocyte serum 48 hours Iater, a long-Iasting survival(>80 days)ofskin allograft was achieved.The B6 mice made tolerant to Balb/c mice kept the potency of re-jecting the skin graft from third party CBA/J mice(H-2￣K),demonstrating the specifity of thetolerance. This tolerance induction protocol would result in the non-specific inhibition of ConAand LPS-induced Iymphocyte proliferations of spleen cells in the tolerant mice. However,thisgeneral immunosuppression could recover in a short period. In contrast,Donor-specific allogeneicresponses,such as MLR and DTH,are completely abrogated.更多还原