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大剂量顺铂联合环磷酰胺、平阳霉素治疗食管癌22例

HIgh dose cisplatin combination chemotherapy for advanced esophageal cancer

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【作者】 董新军孙诗林彭宪忠

【Author】 Dong Xinjun;et al (Department of tumor Bin Zhon Hospital Shan Dong)

【机构】 山东滨州市立医院肿瘤科

【摘要】 我们采用大剂量顺铂联合化疗治疗晚期食管癌22例。化疗方案为PCP(DDP+CTX+PYM)。顺铂剂量为100mg/m ̄2,一次给药,同时水化、利尿。本组病的完全缓解3例,部分缓解7例,总有效率(CR+PR)46%、中位缓解期5个月。化疗的毒副作用有骨髓抑制、消化道反应、脱发、发烧,而肝肾心神经系统毒性反应较轻。

【Abstract】 Twenty-two patients with advanced esophageal cancer were treated by hing close cisplatin(DDP)combination chemotherapy.The regimen was Pcp(DDP+CTX+PYM). DDP was given at adose of 100my/m ̄2 intravenously every 4 weeks. Three patients achieved CR.Seven cases PR. Theresponse rate (CR+PR) was46%. The side effects observed in these patients were as follow:myelosuppression.nausea and vomiting and alopecia and fever. Whereas the side-effects onkidney. liver heart,lung and neurologial system were very few.

  • 【文献出处】 肿瘤防治研究 ,CANCER RESEARCH ON PREVENTION AND TREATMENT , 编辑部邮箱 ,1994年03期
  • 【分类号】R735.105
  • 【被引频次】9
  • 【下载频次】26
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