【摘要】 作者应用抗Ｐ－糖蛋白（Ｐ－１７０）单抗ＪＳＢ－１对１００例急性白血病（ＡＬ）患者进行了检测，结果表明：（１）包括Ｍ３在内的几乎所有ＡＬ亚型均可有ＭＤＲ阳性表达，初诊组ＭＤＲ表达率以Ｍ５（６２．５％）为最高，ＡＮＬＬ（２０％）虽高于ＡＬＬ（８．３％），但差异无显著性意义。（２）初诊组部分患者（１８．２％）呈ＭＤＲ阳性表达，提示ＭＤＲ的内在性。（３）Ｐ－１７０阳性率与ＡＬ临床状况密切相关，难治组Ｐ－１７０阳性率（２０．６±１５．６％）和ＭＤＲ表达率（７８．９％）均显著高于初诊组（７．６±９．３％和１８．２％），ＭＤＲ阳性表达者对化疗不敏感，完全缓解率低，临床预后差。故进行该项检测对指导临床化疗方案设计、预测化疗疗效、判断预后及逆转ＭＤＲ均有重要意义。更多还原

【Abstract】 Abstract Bone marrow specimens from 100 cases of acute leukemia (AL)diagnosed by MIC were detected with fluorescence microscopy for their mdr─1 expression using monoclonal antibody JSB ─1 against p─glycoprotein(P─170).The results showed that almost all subtypes of AL had P─170 expression and M5 of ANLL had a significantly higher expression rate in the newly diagnosed grou.The MDR expression highly correlated with the clinical drug resistance andm prognosi The Positive rate of P─170(20.8% ± 14.9%)and MDR expression(78.9%)ofrefractory group were significantly higher than newly diagnosed group(7.5%±9.8%and 18.2% respectively ).Cases with MDR expression had poor response to chemotherapy and bad prognosis.更多还原