【摘要】 在相同的体外染毒和细胞培养条件下，比较了姊妹染色单体交换（ＳＣＥ）、微核（ＭＮ）、染色体畸变（ＣＡ）、ＤＮＡ解螺旋荧光分析（ＦＡＤＵ）、ＤＮＡ复制合成抑制（ＤＲＳＩ）和非程序ＤＮＡ合成（ＵＤＳ）６项指标对苯井（ａ）芘所致人外周血淋巴细胞遗传损伤的检测敏感性。试用浓度一反应回归直线斜率与观察值距回归直线标准差的比值表示各指标敏感性。结果表明，各指标的敏感性顺序为ＳＣＥ＞ＭＮ＞ＣＡ＞ＦＡＤＵ＞ＤＲＳＩ＞ＵＤＳ。推荐ＳＣＥ和胞质分裂阻断法微核试验为苯并（ａ）芘接触人群遗传损伤监测的首选指标。ＦＡＤＵ试验简便快速，值得在人群监测中试用。更多还原

【Abstract】 omparison of sensitivity of six indices,i.e,SCE,MN,CA,FADU,DRSI and UDS,in detection of genetic damage to human peripheral blood lymphocytes caused by benzo(a)pyrene were studied un-der the same condition for in vitro toxicant treatment and cell cultrure。Ratio of the slope of regression straight line of concentration-response to the standard devitation of regression straigy line from ob-served values was used as an indicator reflecting sensitivity of all the above indices.The results showed the order of sensitivities of all the above indices are as follows: SCE>MN>CA>FADU>DKSI>UDS.SCE and MN(cytokinesis block method)should be choice of indices to monitor genetic damage in human population exposed to benzo(a)pyrene。And it is warranted to use FADU,as a simple,con-venient and rapid method, in human population monitoring。更多还原