【摘要】 报告１００例异基因骨髓移植的预处理相关毒性。预处理方案为标准剂量的环磷酰胺、环已亚硝脲（或甲基环已亚硝脲）及全身照射。毒性分级用Ｂｅａｒｍａｎ等订的标准。结果：１５例无任何毒性发生，最大毒性为ＩＩＩ～ＩＶ级者占１０％；各脏器预处理相关毒性发生率为：口腔粘膜５２％、胃肠道３６％、心脏２５％、膀胱２０％、肝脏１９％、中枢神经系统９％、肺及肾均无近期毒性发生。既往化疗用过柔红霉素者心脏的预处理相关毒性发生率高；既往用过马利兰和（或）ＣＴＸ可使膀胱的预处理相关毒性发生率增加；而预防性地应用前列腺素Ｅ＿１可有效地减少膀胱毒性。更多还原

【Abstract】 reparative regimen with high dose chemoradio-thera py before allogeneic bone marrow tran splantation（allo-BMT ） is toxic to marrow recipients。Our prepara-tive regimen consists of cyclophosphamide l.8g·m￣（-2）/dfor 2 days,CCNU 200 mg·m￣（-2）/d or me-CCNU250mg·m￣（-2）/d for one day and total hixly irradiation（TBI）of 6.6～7.7 Gy, To evaluate regimen-related tox-icity,we carried Out a retrospective study concerning100 patients conditioned with this regimen. All patientsreceived graft versus host disease（GVHD） prophylaxis.Regimen-related toxicity was graded according to theseattle’s transplantation toxicity system. Morbidity wasassessed in eight organs:heart,bladder,kidneys,lungs,liver,mucosa,centraI nervous system and gut.Toxicity was graded on days 0,7,14 and 28 after trans-plantation,from grade 0（no toxicity）to grade IV（fataltoxicity）.Fifteen patients did not show any toxicity.Grades III-IV toxicity were uncommon（10%）.The in-dividual organ toxicity was stomatitis（52%）,gastroin-testinaI toxicity（36%）,cardiac toxicity（25%）,bladdertoxicity（20%）,hepatic toxicity（19%）,central ner-vous system（CNS）toxicity（9%）and pulmonary andrenal toxicity（0%）.Bladder toxicity occlired more com-mon in patients who received cyclophosphamide and/orbulsulfan before BMT. Cardiac toxicity was frequent a-mong recipients who received DNR before BMT.Prostaglandin E₁ could reduce the incidence of bladdertoxicity.更多还原