【摘要】 应用离体作功兔心模型，研究不同浓度的人参总皂甙（ＧＳ）对心肌缺血再灌注损伤的影响。通过心肌活检电镜下线粒体记分和血流动力学指标的测定，认为人参总皂甙作为心脏停搏液的添加剂，在２０～８０ｍｇ／Ｌ的浓度范围内，具有抗心肌缺血再灌注损伤作用；并随浓度递增而增强。但当浓度达１６０ｍｇ／Ｌ时则失去上述作用，反有加重心肌缺血再灌注损伤的倾向。更多还原

【Abstract】 This experiment studied the effects of Ginsenosides as a additive agent to cardicplegic solution on ischemic and reperfused myocardium and the concentration-response relationship using isolated working rabbit heart.The samples of the myocardial biopsy were observed and mitochondria were scored under the electron microscope and hemodynamic parameters were recorded.The results showed that the dosage of Ginsenosides in the range of 2080mg/L has the protective effects on myocardial ischemia and reperfusion injury.And the effects increase when the concentration of Ginsenosides is increased.When the concentration of Ginscnosides was 160mg/L,the above effects were lost,the myocardial ischemia and reperfusion injury were aggravated.更多还原