【摘要】 我们在成功地复制出肝性脑病（ＨＥ）大白鼠模型的基础上，应用放射受体分析法对ＨＥ大鼠端脑、间脑、脑干和小脑的粗制突触体膜进行［￣３Ｈ］ＰＫ１１１９５受体结合分析，并设立对照组。结果表明，ＨＥ较对照鼠仅端脑和间脑的外周型苯二氮享受体（ＰＢＲ）结合位点数量显著增加（分别为Ｐ＜０．００１和Ｐ＜０．０５），以端脑尤甚；仅脑干ＰＢＲ亲和力升高（Ｐ＜０．０５）。提示ＨＥ发病与不同脑区ＰＢＲ改变导致的脑组织能量代谢障碍有关。本研究结果对于深入探讨ＨＥ发病机理和指导临床应用ＰＢＲ桔抗剂治疗ＨＥ具有一定意义更多还原

【Abstract】 AbstractBy means of radioligand binding assay,peripheral-type benzodiazepine receptors(PBR)in the telen-cephalon,diencephalon,brain stem and cerebellum,were investigated in a rat model with hepatlc en-cephalopathy (HE),Binding to PBR was studied using[￣3H] PK11195 as radioligand. It was demonstrated thatonly densities(Bmax)of [￣3H] PK11195 binding tocrude synaptosomal membranes in the telencephalon,diencephalon of HE rats were obviously increased ascompared with those of controls(P< 0. 001 and P<0. 05 respectively). Increased affinities(Kd) were onlyobserved in brain stem(P<0. 05 ).The resultsshowed that the alterations of PBR in different regionsof the brain play a significant role in the pathogenesisof HE.更多还原