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大白鼠脑皮质缺血区的同种胎脑组织移植

Transplantation of homologous embryonic contical tissue into the ischemic regions of brain in adult rats

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【作者】 李小勇魏玉屏刘学礼

【Author】 Li xiao-yong, et al. (BeijingNeurosurgical Institute Beijing 100050.)

【机构】 北京市神经外科研究所!北京100050山西医学院生化教研室山西医学院第一附属医院神经外科

【摘要】 将同种胎脑组织移植入大白鼠脑皮质缺血区内获成功。结果发现:1.脑皮质缺血区内的同种胎脑组织移植成活率为76.47%。其中缺血后立即移植组成活率较低.2.A与B组移植物生长得均较大且表面光滑;C组移植物较小且呈分辨状。大体观移植物与正常脑组织一致。3.镜下移植物为神经组织。A与B组移植物周围炎性反应较重,与宿主脑的神经纤维联系较少;C组移植物周围炎性反应轻,与宿主脑的纤维联系较广泛。

【Abstract】 Transplants of homologous conical tissue have been transplanted into the ischemica regions of brain-in adult rats,which has not been seen in previous reports. And then their histological structures have been observed through tissue slices. The results of our experiment are: 1). The homologous embryonic conical tissue transplanted in the ischemic region of host brain survived for 62 to 120 days. The survival rate of transplants in all the transplantation groups is 74. 47 %, and among these groups, the survival rate in Group A (45. 5%) is significantly lower than in Group B (90.91%) and Group C (83. 33) in statistics (P<0. 05).2). The volume of transplants in Group A and Group B are larger than in Group C, and the color and the characters of survived transplants are similar to the normal brain tissue of the control group. 3). The results observed under microscope as follows: All the transplants are of nerve tissue; Surrounding the transplants, the inflammatory responses in Group A and Group B are more severe than that in Group C ; Nerve fiber connections between transplant and host brain are more extensive in Group C than that in other transplantation groups.

  • 【文献出处】 中华实验外科杂志 ,Chinese Journal of Experimental Surgery , 编辑部邮箱 ,1994年05期
  • 【分类号】R651.11
  • 【下载频次】12
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