【摘要】 对２４例胎胰及３例成人胰腺用ＨＬＡ－Ａ、Ｂ、Ｃ、ＤＲ单克隆抗体进行免疫组织化学法染色，观察其阳性细胞的形态和分布，并行网络计数。ＨＬＡ－Ａ、Ｂ、Ｃ、ＤＲ抗原主要表达于淋巴样细胞与树突状细胞，胎龄愈大阳性细胞数愈少，但树突状细胞比例增大。提示成人胰腺内ＨＬＡ－Ａ、Ｂ、Ｃ、ＤＲ抗原阳性树突状细胞比胎胰内的更成熟，因而胎胰的免疫原性比成人低。但胎胰内含有大量ＨＬＡ抗原，一旦被启动则排斥反应不弱于成人胰腺。更多还原

【Abstract】 The pancreata from 24 fetuses and 3 adults were stained by immunohistochemistry ABC method with monomorphic HLA- A, B, C, DR monoclonal antibodies. The number, morphology and distribution of the positive cells were counted and observed. The expression of HLA-A , B , C , DR antigen was dected mainly on dendritic and lymphoid cells. While along with the fetus growth, the number of positive cell was decreased, but the proportion of dendritic positive cell was increased gradually. This suggested that the morphology and function of HLA- A, B, C. DR positive dendritic cells in adult pancreas were more complete and mature than those in fetus, and that the immunogenicity of fetal pancreas may be more weak than that of adult pancreas. But there were still a number of HLA-A, B, C, DR antigens in fetal pancreas, the rejection of the fetal pancreas would be not less weak than that of adult pancreas.更多还原