【摘要】 立体选择性合成（２Ｓ，３Ｓ）－３－氨基－２－羟基－４－苯基丁酸汝奇，木村徹，木曾良明（日本国京都药科大学）α－羟基－β－氨基酸在许多有生物活性的化合物中起着重要作用。化合物ｋｙｎｏｓｔａｔｉｎｓ［ＫＮＩ－２７２（１）和ＫＮＩ－２２７（２）］已显示强效...更多还原

【Abstract】 S, 3S) -3-Amino-2-hydroxy-4-phenylbutyric acid (allophenylnorstatine, APNS), a core unit of HIV protease inhibitors, was synthesized diastereoselectively by improving the original synthetic route according to the Cram’s rule of asymmetric induction. The ratio 2S/2R was increased from 42/58 to 67/33.更多还原