【摘要】 用序贯试验方法，观察了８例绝经后骨质疏松（ＰＭＯＰ）者，用密钙息（鲑鱼降钙素）肌肉注射，治疗１个月前、后钙代谢平衡等指标的情况。结果显示：（１）钙平衡值差值累计曲线触及上界，结论为促钙正平衡（α＝β＝０．０１，δ＝１．２３）；（２）肠ＡＫＰ活性增加（Ｐ＜０．０５）；（３）肠钙净吸收率增加（Ｐ＜０．０５）。促钙正平衡作用的机制之一，可能与密钙息使肠ＡＫＰ活性增加、肠钙吸收转运增加有关。更多还原

【Abstract】 Miacalcic has shown some positive effects on calcium metabolism. With sequential test, the effect of Miacalcic on calciummetabolic balance was studied in 8 patients with postmenopausal osteoporosis. The results showed that after one month-treatment,calcium balance value improved significantly(∝=β=0. 01.δ=1. 23), for its accumulated balance value curve reached the positivecritlcal line. The intestinal AKP activity and the rate of intestinal calcium absorption also increased significantly(P<0.05). Thaseeffects could be ascribed to stimulation of renal 1-hydroxylase activity,and increase in synthesis of calcitriol, AKP activity and in-testinal calcium absorption.更多还原