【摘要】 单次静注爱肌松（０．３ｍｇ·ｋｇ－１，对照组）于３．１７±０．８１分钟（ｘ±ｓ）可获得满意的气管插管条件。预注组（１０例）首次量０．２７ｍｇ·ｋｇ－１于预注剂量（０．０３ｍｇ·ｋｇ－１）后５分钟给予，可使爱肌松的起效时间缩短至０．９３±０．１７分钟（Ｐ＜０．００１），ＴＯＦ无反应期、２５％和９０％恢复时间两组无显著差别（Ｐ＞０．２５）。全部病例均获得了良好的气管插管条件，预注的优点还在于能评估患者对所选用非去极化肌松药的敏感性。预往后ＴＯＦ肌电图Ｔ１抑制＞１０％较无明显ＴＯＦ抑制者肌松恢复时间显著延长（Ｐ＜０．０５）。同时发现吸入安氟醚可使爱肌松作用时效延长。更多还原

【Abstract】 A satisfactory condition for tracheal intuhation in 3.17±O. 81min could be pro- ided with a single dose of alloferin 0. 3mg/kg in 6 patients as control group. An initial dose of alloferin 0. 27mg/kg was given 5 minutes after a priming dose of 0. 03mg/kg iv in other (10 patients ) group, the onset time of alloferin for intubation was shortened to 0. 93 ±0. 17min (P< O. 001 ),the total paralysis duration and 25% and 7o% recovery time were not different between the two groups. Good nditions that facilitated the endotracheal intubation were achieved in all patients. An added advantage of "priming" is that the patient’s sensitivity to nondepolarizing muscle relaxants can be estimated by observing the response to the Priming dose. The duration of muscular relaxation had been doubly prolonged when enflurane was inhaled simultane- ously.更多还原