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体外冲击波对肾脏生物学效应的实验研究

An experimental study of biological effects of extracorporeal shock wave on kidney

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【作者】 夏同礼梁丽莉孔祥田蔡碧娟郭应禄

【Author】 Xia Tong-li; Liang Li-li; Kong Xiang-tian; et al. (Institute of Urology,Beijing Medical University, Beijing 100034)

【机构】 北京医科大学泌尿外科研究所

【摘要】 雄性家兔45只,分为3组,分别接受三个能量级(20kV,750SW;14kV,1500SW;10kV,3000SW)体外冲击波处理。结果表明,2组动物急性肾损伤程度较其它两组病变轻微。体外冲击波对肾脏的生物学效应表现为尿酶γGT升高;超微结构显示肾小管上皮细胞变性坏死;组织学显示肾内和肾周出血。实验第28天的生物学效应表现为吸收和(或)纤维化修复。体外冲击波能量(包括电压和冲击次数)与其对肾脏生物学效应程度相关。

【Abstract】 male rabbits were divided into three groups and were treated with three energy levels (20KV, 750SW; 14kv,1 500kv; 10kv, 3 000kv) of extracorporeal shock wave (ESW) respectively. The results suggest that acuterenal injury was minimal in the Ⅱ group as compared with the other two groups.The biological effects of ESW on kidney caused an increase of γGT in urine,degeneration and or necrosis of tubular cells in ultrastructure, and intrarenal and perirenal bleeding in histology.The biological effects were renovated with absorbtion and or fibrosis in 28 days after ESW. There was a noted relationship between the energy level (generator voltage and shock wave number) and the biological effect on kidney.

【关键词】 体外冲击波肾脏生物学效应
【Key words】 ESWLKidneyBiolgical availability
  • 【文献出处】 中华泌尿外科杂志 ,CHINESE JOURNAL OF VROLOGY , 编辑部邮箱 ,1994年04期
  • 【分类号】R691.4
  • 【被引频次】19
  • 【下载频次】74
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