【摘要】 笔者对原发性肝癌的主要危险因素饮水污染、乙型肝炎病毒感染、黄曲霉毒素污染间相互作用的关系进行了研究。运用相对危险度函数参数簇模型（从次相加结构到超相乘结构）来拟合病例对照资料，评判何种模型为佳。本文的结果提示：肝癌发生的主要危险因素饮水污染、乙型肝炎病毒感染、黄曲霉毒素（ＡＦＢ１）污染间存在协同作用；ＡＦＢ１与另两个肝癌主要危险因素乙型肝炎和饮沟塘水的联合作用似一种倾向于相加的结构，而乙型肝炎和饮沟塘水的联合作用似一种偏向于相乘的结构。不同模型间数量上的差别对病因学的解释和预防措施实践具有重要意义。更多还原

【Abstract】 This paper evaluates the combined effect ofHBsAg,drinking water and aflatoxin B1(AFB1)on the primary hepatocellular carcinoma(PHC)in a case-control study which was carried outin Fusui,Guangxi.We used relative risk model(from subadditive to supermultiplicative)tofit the relationship.The results showed thatthe combined effect of HBsAg infection anddrinking pond-ditch water is nearly multiplica- tive, and the combined effect of HBsAg infectionand AFB1 intake as well as drinking pond-ditchwater and AFB1 intake were nearly additive.更多还原