【摘要】 采用常压间竭低氧模型，观察了钙通道拮抗剂尼群地平（Ｎｉｔ）、硝苯吡啶（Ｎｉｆ）、内皮依赖性血管舒张因子（ＥＤＲＦ）合成前体Ｌ－精氨酸（Ｌ－Ａ）对大鼠慢性低氧性肺动脉高压的预防作用。结果提示：三者均能预防低氧性肺动脉高压形成和减轻低氧引起的右室肥大；Ｎｉｔ、Ｎｉｆ与Ｌ－Ａ比较无显著性差异（Ｐ＞０．０５）；Ｎｉｔ对低氧性肺动脉高压的降压作用较Ｎｉｆ稍好。更多还原

【Abstract】 xperiments were carried on rats to study the pre-ventive effects of calcium channel blockers Nitrendipine,Nifedipine and L-Arginine (L-Arginine is the physio-logical precursor of nitric oxide in endothelium-depen-dent relaxation ) on chronic intermittent hypoxia inducedpulmonary hypertension , on the right ventricular hyper-trophy and pulmonary vascular pathologic changes. Theresults showed ① Nitrendipine, Nifedipine and L- argi-nine played significant role in preventing chronic hypoxicpulmonary hypertension and the right ventricular hyper-trophy. ② There was no significant difference betweenNitrendipine, Nifedipine and L- arginine ih preventinghypoxic pulmonary hypertension (P>0. 05).③ Ni-trendipine was better than Nifedipine in reducing thehypoxic pulmonary hypertension.更多还原