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硒锌对培养兔和人胚软骨细胞生长的影响

The Effect of Selenium and Zinc on the Growth of-Cultured Chondrocytes of Rabbit and Human Embryo

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【作者】 曹峻岭熊咏民李斯纯

【Author】 / Cao Junling,et al. Institute of Endemic Bone Diseases,Xi’anMedical University Xi’an 710061

【机构】 西安医科大学地方性骨病研究所

【摘要】 本实验在培养液中加入一定量的硒,锌对一代兔和人胚关节软骨细胞进行培养192小时。结果显示:补充适量的硒或锌均能促进培养软骨细胞的生长代谢,但硒过量则损害于软骨细胞,若同时补给适量的锌和硒,其效果有相加的作用。补锌和补硒的效果可能为硒+锌>锌>硒。同时表明体外培养软骨细胞的基质代谢能很快进入平衡状态。人胚软骨细胞生长慢于兔,基质胶原代谢慢于蛋白多糖

【Abstract】 AbstractRabbits and human embryo articular chondrocytes were recultured in the media supplied with selenium andzinc for 192 hours. The result showed that zinc and seleni-um supplied media at a given concentration could promotethe growth metabolism of the cultured chondrocytes;how-ever,super-concentrated selenium in the media could dam-age the growth metabolism of the chondrocytes under cul-ture. The effect of promotion of the metabelism of thechondrocytes in culture was most eminent when zinc andselenium were added simultaneously,then follows the sin-gle addition of zinc,and single addition of selenium. Thegrowth of chondrocytes of human embryo was slower thanthat of the rabbit.

【关键词】 软骨细胞
  • 【文献出处】 中华骨科杂志 ,CHINESE JOURNAL OF ORTHOPAEDICS , 编辑部邮箱 ,1994年10期
  • 【分类号】R329-33
  • 【被引频次】1
  • 【下载频次】59
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