【摘要】 应用体外集落形成率研究了１０，２０，３０ｍｇ／ｍｌ绞股蓝对￣（６０）Ｃｏ单次６Ｇｙ照射后人胃腺癌ＳＧＣ－７９０１细胞存活比率的改变，发现用药２小时后加６Ｇｙ的细胞存活比率比单纯６Ｇｙ照射后提高１６Ｇｙ照射后加药６小时，结果也显示细胞存活比率提高。细胞周期分布的材料表明１０ｍｇ／ｍｌ绞股蓝作用２小时后即有明显细胞周期分布改变，Ｓ期细胞明显增加和Ｇ＿１期、Ｇ＿２＋Ｍ期细胞比例减少。这可能与绞股蓝促进细胞增殖，以及ＰＬＤＲ能力有关。更多还原

【Abstract】 AbstractThis study was carried out to investigate if Gynostemma Shanhai Pentaphyllum(GP)couldalter the surviving fraction of SGC-7901 cells irradiated by single dose(6 Gy)of Cobalt-60 Ourdata showcd 2 hr-pre -irradiation treatment of GP(10, 20, 30 mg/ml)gave a higher survivingfraction as cornpared to 6Gy only. And 6 hr-post-irradiation treatment of GP also gave a high-er surviving fraction as compared to 6 Gy alone. Cell kincties analysis by flow cytometry showed asignificant increase of percentage of S-phase with the decrease in percentage of G1 and G2+Mphase, The possible mechanism of the enhancment by GP is dicussed.更多还原