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肢端肥大症的放射治疗

RADIOTHERAPY OF ACROMEGALY

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【作者】 张福泉周觉初史轶繁刘兰

【Author】 Zhang Fuquan; Zhou Juechu; Shi Yian,et al.(Peking Union Medical College Hospital , Beijing)

【机构】 北京市协和医院

【摘要】 报告363例肢端肥大症的治疗结果。单纯放疗205例,手术加放疗158例。以治疗前后血浆生长激素变化为疗效判定标准,单纯放疗和手术加放疗的3、5年完全缓解率分别为24.1%、47.0%和29.7%、54.8%。疗效与剂量有关。复发率为9.1%,45Gy以下发发率高。垂体前叶功能低下是最常见的并发症。放疗后生长激素下降缓慢,仍可对组织和器官起作用。

【Abstract】 AbstractFrom 1954 to 1989, 363 patients with acromegaly were treated by radiotherapy. Of these,205 received radiotherapy alone and 158 , postoperative radiotherapy。 Treatment result was eval-uated on the basis of growth hormone, Complete remission rates of 3-years and 5一years in ra-diotherapy alone group were 24.1%, 47.0%and 29.7%, 54.8%in postoperative radiotherapygroup, respctively。 The results of treatment were related to radiation dose. The recurrence ratewas 9.1%, Hypopituitarism is one of the most common complications. Because of slow decreaseof growth hormone after radiothrapy,it still effects the tissues and organs before growth hormonereturn up to normal level.

【关键词】 肢端肥大症生长激素放射治疗
  • 【文献出处】 中华放射肿瘤学杂志 ,CHINESE JOURNAL OF RADIATION ONCOLOGY , 编辑部邮箱 ,1994年04期
  • 【分类号】R584.11
  • 【被引频次】3
  • 【下载频次】40
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