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三组高晶——高胶复合液复苏兔失血性休克的观察

Hypertonic Saline/Mannitol (HSM) to Reverse Severe Hemorrhagic Shock in Rabbits

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【作者】 罗学宏黄志军宁阳根汤爱国肖桂林

【Author】 Luo Xue hong, Huang Zhi jun, Ning Yang gen, et al.The Emergency Dept. of Xiang ya Hospital, Hunan Medical University, Changsha,Hunan 410008.

【机构】 湖南医科大学附属湘雅医院急诊科

【摘要】 雄性家兔18只,随机分为高渗盐/右旋糖酐治疗组(HSD组),高渗盐/甘露醇治疗组(HSM组),高渗醋酸盐/甘露醇治疗组(HAM组)。经股动脉放血,结果表明,三组小剂量液体(4ml/kg体重)均可在短时间内明显升高急性失血兔的血压,但3组间比较,HSM升压,稳定的时间更长,动物的存活时间长。试验结果提示:HSM较好地升压,稳压,延长失血性休克兔存活时间,值得进一步研究并临床应用,HAM在稳定酸碱平衡方面,有较好的效果。

【Abstract】 Eighteen male health rabbits were randomly divided into 3 groups ( n =6), bled to a mean blood pressure of 5.3 kPa for 30 minutes and resuscitated with hypertonic saline/mannital (the HSM group), hypertonic saline/dextran (the HSD group)and hypertonic acetate/mannitol (the HAM group) at a Low dose of 4ml/kg. Then we compared the effects of HSM with those of HSD and HAM. The results showed that all of them could raise the blood pressure rapidly, but longer surviving time and higher blood pressure were found in the hemorrhagic shock in the HSM group. This indicated that HSM could keep higher BP for longer time than HSD and HAM , the surviving time in the HSM group was significantly longer than in the other two groups.

  • 【文献出处】 中华创伤杂志 ,CHINESE JOURNAL OF TRAUMATOLOGY , 编辑部邮箱 ,1994年05期
  • 【分类号】R605.971
  • 【被引频次】9
  • 【下载频次】206
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