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双黄连气雾剂与注射剂的药效学及临床应用研究

Studies on Pharmacodynamics and Clinical TherapeuticEffccts of Aerosol and Injection of Shuanghuanglian

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【作者】 徐凯建王跃红胡君茹吴琳华孙考祥

【Author】 Xu Kaijian; Wang Yaohong ;Hu Junru; Wu Linhua and Sun Kaoxiang(Institute of Clinical Pharmacy and Pharinacology,Harbin Medical University 150086)

【机构】 哈尔滨医科大学临床药学药物研究所

【摘要】 药效学实验表明:双黄连两种剂型均能增强人外周血NK细胞活性,具有促进淋巴细胞生成α-干扰素的能力,同时具有广谱抑菌、抑病毒作用。以注射剂生物利用度为100%,气雾剂绝对生物利用度为96.88%(黄芩甙)和96.69%(绿原酸),临账观察表明:气雾剂与注射剂的显效率分别为84%和83%,总有效率分别为92%和93%。

【Abstract】 he results show that both aerosol and injection of shuanghuanglian can increase. the activity of NK cells in pe-ripheral blood of the human body as well as the ability of lymphocyte to produce α-interferon. Their broad-spectrumantiseptic and virus-inhibiting actions have also been confirmed.The absolute bioavailability of aerosol was 96.88%(baicalin) and 90. 69% (chlorogeniacid).The significant response rate of aerosol and injection was 84% and 83% re-spectively. The total response rate was 92% and 93% respectively.

  • 【文献出处】 中国中药杂志 ,CHINA JOURNAL OF CHINESE MATERIA MEDICA , 编辑部邮箱 ,1994年11期
  • 【分类号】R285.6
  • 【被引频次】32
  • 【下载频次】300
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