【摘要】 应用免疫组化ABC法,检测58例胃癌及其旁正常粘膜表皮生长因子(EGF)及其受体(EGFR).结果,胃癌EGF阳性36例(62.l%),EGFR阳性29例(50.0%);正常粘膜EGF、EGFR阳性各3例(5.2%).两组间差异有显著性(P<0.005),提示EGF、EGFR与胃癌关系密切.EGF随癌浸润加深阳性率增高.有转移时胃癌组织EGF和EGFR的阳性表达显著高于无转移者(P<0.01).因此,EGF、EGFR的表达程度可反映胃癌恶性程度.更多还原

【Abstract】 Using immunohistochemical ABC method, the epidermal growth factor(EGF) and its receptor(EGFR)were examined in 58 gastric cancer tissues and 58 normal gastric tissues. Our study showed that EGF and EGFR were positively stained in 36 cases (62. 1%) and 29 cases(50. 0%) respectively. EGF and EGFR in experimental group were significantly higher than in the control group (P<0. 005). EGF was detected more frequently in deeply invasive carcinomas than in superficially invasive carcinomas. The increase of EGF and EGFR in gastric cancer tissues were significantly higher in metastatic disease(P<0. 01). It is concluded that EGF and EGFR expression are indicators of the malignancy of gastric cancer.更多还原