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肺靶向顺铂白蛋白微球含量的衍生化测定法

Derivative assay of bovine serum albumin microspheres loaded cisplat-inum for pulmonary targeting

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【作者】 张明侯世祥龚涛程宇慧廖工铁

【Author】 zHANG Ming;HOU Shi-xiang; GONG Tao; CHEN Yu-hui;LIAO Gong-tie(School of Pharmacy West China Universily of Medical Sciences,Chenxdu 610041)

【机构】 华西医科大学药学院

【摘要】 采用衍生化原理,使二乙基二硫代氨基甲醚钠(DDTC)与抗癌药顺铂(CDDP)反应,致紫外吸收度增加,并依据肺靶向顺铂白蛋白微球研制及其质量评价要求,建立了两种含量测定方法。一法回收率99.88%、RSD=0.69%,用于背景干扰小的微球释放度测定;二法回收率96.15%、RSD=1.34%,用于干扰大的微球包封率测定。方法简便、快速,效果满意。

【Abstract】 In this methiod the principle of derivatization was employed.Sodium di-ethyldithiocarbamate(DDTC)reacted with anticancer agent cis-dichlorodiammine platinum(CDDP)to form Pt(DDTC)2,absorption of which increased.To study bovine serum albumin mi-crospheres loaded CDDP for pulmonary targeting and to evaluate its qualities,we developed towmethods for determining CDDP. The recovery of method 1 was 99.88%,RSD 0.69%, whichcan be used to determine the CDDP release from microsperes when the back-ground interferenceis low,The recovery of method 2 was 96.15%,RSD 1.34%,which can be used to determine therate in capsulation when the back-ground interference is high. These methods are simple andrapid.

【基金】 国家教委博士点基金
  • 【文献出处】 中国药学杂志 ,CHINESE PHARMACEUTICAL JOURNAL , 编辑部邮箱 ,1994年06期
  • 【分类号】R944
  • 【被引频次】6
  • 【下载频次】137
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