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苯唑青霉素对丁胺卡那霉素药动学的影响
Influence of oxacillin on pharmacokinetics of amikacin on rabbits
【摘要】 采用微量微生物法对丁胺卡那霉素(AMK)单用及AMK与苯唑青霉素(OXA)合用后,兔体内AMK血药浓度进行测定;药时数据用MCPKP软件经IBM计算机处理,并对两组药动学参数进行了统计学处理,结果表明OXA对AMK的药动学有显著的影响。
【Abstract】 Amikacin(AMK)in the serum of rabbits was determined by the improved microbiol-ogy method and was compared with combination of AMK and oxacillin(OXA).The concentrationtime were disposed with MCPKP propram and IBM microcomputer,The results showed thatOXA had apparently influence on pharmacokinetics of AMK in rabbits.
- 【文献出处】 中国药学杂志 ,CHINESE PHARMACEUTICAL JOURNAL , 编辑部邮箱 ,1994年06期
- 【分类号】R978.1
- 【下载频次】52