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心脏直视手术再灌注时血浆和心肌组织氧自由基及超微结构改变的观察

CHANGES OF PLASMA AND MYOCARDIAL OXYGEN FREE RADICALS IN PATIENTS WITH OPEN HEART SURGERY DURING REPERFUSION AND OBSERVATION OF MYOCARDIAL ULTRASTRUCTURE

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【作者】 李敬连刘志伟张朝满庄瑰霍张玉琛

【Author】 Li Jing-Lian; Liu Zhi-Wei;Zhang;Chao-Man;et al.(Department of Cardiovascular Surgery,Affiliated Hospital of Chengde Medical College,Chengde)

【机构】 河北省承德医学院附属医院心胸外科

【摘要】 为进一步探讨心脏直视手术患者血浆、心肌组织氧自由基变化及临床意义,对15例心脏直视手术患者血浆、心肌组织丙二醛(MDA)含量及超氧化物歧化酶(SOD)活性进行测定,并对心肌组织进行超微结构观察。结果表明,血浆MDA含量在体外循环过程中逐渐升高,心脏复跳后较缺血期更明显,而血液SOD活性呈下降趋势;心肌组织缺血再灌注后MDA含量较心脏停跳前、停跳后明显增加,而SOD活性降低。心脏复跳后,心肌组织超微结构损害较停跳后更明显.这一结果提示,心肌组织氧自由基的产生主要是在再灌注期,是心肌缺血再灌注损伤的重要原因。

【Abstract】 In order to observe the changes and clinical significance of oxygen free radicals in patients with open heart surgery,the content of malondialdehyde(MDA)and the activity of superoxide dismutase(SOD)in plasma and myocardium were measured in 15 cases and the myocardial ultrastructure was also observed.The results showed that the content of plasma MDA increased during cardiopulmonary bypass,especially during reperfusion,on the other hand activity of SOD decreased.The content of myocardial MDA markedly increased during reperfusion than during myocardial ischemia.Myocardial ultrastructure showed more damage in the reperfusion than in the ischemia period.The result revealed that myocardial oxygen free radicals are formed primarily during reperfusion period, which is responsible for myocardial damage during reperfusion.

【关键词】 心脏直视手术氧自由基
【Key words】 Open heart surgeryOxygen free radicals
  • 【文献出处】 中国循环杂志 ,CHINESE CIRCULATION JOURNAL , 编辑部邮箱 ,1994年04期
  • 【分类号】R654.2
  • 【被引频次】2
  • 【下载频次】31
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