【摘要】 观察了ＩＣＩ１２８４３６（Ｓｔａｔｉ），一种新型醛糖还原酶抑制剂（ＡＲＩ），使体外培养时小鼠胰岛山梨醇形成减少后，葡萄糖诱发快速与慢速相胰岛素释放的变化情况。培养４８或９６小时后，葡萄糖诱发快速或慢速相胰岛素释放，ＡＲＩ组（１０ｍｇ／Ｌ）与对照组胰岛比较均无显著性差异。说明ＡＲＩ虽可使胰岛山梨醇形成减低，但其对葡萄糖诱发胰岛素释放无明显影响。提示胰岛山梨醇可能无确切促进胰岛素分泌的作用。更多还原

【Abstract】 The changes of both rapid and slow phases of glucoseinduced insulin release after the sorbitol formation decreased by ICI 128436(Statil), a new aldose reductase inhibitor (ARI)in the isolated mouse pancreatic islet culture were observed. After cultivation for 48 or 96 hours, there were not significant differences of both rapid and slow phases of glucose-induced insulin release between the ARI(10mg/L)and the control groups. It demonstrated that ARI had no significant influence on glucose-induced insulin release although it might reduce the sorbitol formation in the islets. It suggests that sorbitol in the isolated pancreatic islets may not exert an insulinotropic action.更多还原