节点文献

糖尿病合并冠心病患者Apo-B基因位点多态性的观察

Apolipoprotein B gene allelic polymorphism in Diabetie patients with coronary heart disease

  • 推荐 CAJ下载
  • PDF下载
  • 不支持迅雷等下载工具,请取消加速工具后下载。

【作者】 靳红曲万云张爱君谈春荣赵晓春

【Author】 Jin Hong;Wan Qu-yun;Zhang Ai-jun;et al(Department of Internal Medicine,General Railway Hospital,Beijing 100038)

【机构】 北京铁路总医院内科

【摘要】 本文研究了Apo-B基因位点多态性与糖尿病合并冠心病患者之间的关系,应用PCR技术和聚丙烯酰胺凝胶电泳测定30例糖尿病合并冠心病病人,25例糖尿病病人和44例正常人的基因型,示Apo-B基因808bp等位基因组在糖尿病合并冠心病病人的基因频率比正常人显著增高。808bp等位基因与血浆高含Apo-B的脂蛋白水平有显著相关。

【Abstract】 Previous studies suggested that some apolipoprotein B (Apo-B) locus alleles are associated with coronary heart disease(CHD).We examined the possible association of the Apo-B gene polymorphism in diabetes mellitus (DM) with CHD. Using the polymerase chain reaction(PCR) and polyacrylanide gel electrophoresis,the genotypes were determined in 30 cases of DM with CHD,25 cases of DM without CHD, 33 cases of CHD without diabetes and in 44 cases of healthy subjects,the Apo-B 808bp alleles appeared much more frequent in diabetics with CHD than in the healthy.There was significant association between the 808bp alleles and high serum Apo-B levels.

  • 【文献出处】 中国糖尿病杂志 ,CHINESE JOURNAL OF DIABETES , 编辑部邮箱 ,1994年02期
  • 【分类号】R587.1
  • 【被引频次】1
  • 【下载频次】45
节点文献中: 

本文链接的文献网络图示:

本文的引文网络