【摘要】 雷公藤内酯（triptolide,Tri）sc.ip及ig0.05—0.3mg·kg^-1对渗出性和增殖性炎症均有明显抑制作用。Tri 0.2mg·kg^-1ip引起胸腺萎缩,对摘除双侧肾上腺大鼠Tri可使角叉菜足跖肿胀的作用消失,并能使大鼠肾上腺内抗坏血酸含量明显降低,且会被地塞米松所阻断。但对炎症组织释放的prostaglandins E含量没有影响。更多还原

【Abstract】 Triptolide (Tri) was isolated from Tripterygium -wilfordii Hook f. Tri 0. 1 - 0. 2 mg·kg-1 sc or 0. 15 -0. 3 mg·kg-1 ig inhibited markedly the increased vascular permeability induced by ip 0. 7 % HAc in mice. Tri 0. 05 - 0. 1 mg·kg-1 ip or 0. 15 - 0. 3 mg· kg -1 ig inhibited hind paws swelling induced by sc 0. 15 ml carrageenan and also inhibited the same swelling induced by sc 2. 5 % formaldehyde 0. 1 ml in rats. Tri 0. 05 - 0. 1 mg·kg -1 ip inhibited markedly proliferation of granuloma induced by sc implantation of cotton-pellets in rats, but 0. 2 mg·kg-1 ip can not inhibit the same swelling induced by sc 0. 15 ml carrageenan in adrenalectomized rats. Tri 0. 2 mg·kg-1 ip decreased markedly weight of thymus. Tri 0. 2 mg ·kg-1 ip, but 0. 1mg · kg -1 ip did not reduced the content of ascorbic acid of adrenal gland in rats. Tri 0. 2 mg·kg-1 ip did not decrease the pro-staglandin E content in inflammatory tissues. These results indicate that high dose of Tri can stimulate the pituitary-adrenal axis.更多还原