【摘要】 本文用苯福林或硝普钠iv于麻醉大鼠,引起BP最大变化（ΔBP）所致反射性HR最大变化（ΔR-R）的回归直线斜率为动脉压力感受性反射敏感性（BRS）的指标,测得iv m-Nis 5,10,20μg·kg^-1均明显降低BRS（P<0.01）,m-Nis抑制BRS可能是直接作用于颈动脉窦压力感受器。更多还原

【Abstract】 Baroreflex sensitivity (BRS) in anesthetized rats was measured as the slope of the regression line of the concomitant maximal change in heart rate (AR-R) and blood pressure (ABP) induced by bolus iv phenylephrine or sodium nitroprusside. m-nisoldipine (m-Nis) iv 5, 10, 20 μg · kg-1 depressed the BRS (2.6 ± 0.2, 2.4 ± 0.3, 1.6 ± 0.2, or 1.7 ± 0. 1, 1.6 ± 0.2, and 1. 4 ± 0. 2 ms · kPa-1, respectively ) compared with before medication (P < 0.01). m-Nis may act directly on carotid sinus to depress the BRS, but not through cardiac β or M receptor nor through central nervous system.更多还原