【摘要】 用传统微电技术研究了沙棘总黄酮（TFH）对心肌细胞的电生理作用,TFH 100—200 mg·L^-1使豚鼠心室乳头状肌APD缩短,收缩力下降,培养大鼠心肌细胞APD缩短及4相除极斜率降低。TFH 100 mg·L^-1可抑制毒毛花甙G诱发豚鼠乳头状肌心律失常。提示,上述作用主要与TFH抑制心肌细胞Ca²⁺内流影响心肌细胞内Ca²⁺储库有关。更多还原

【Abstract】 The effects of total flavones of Hippophae rhamnoides L (TFH) were evaluated using conventional microelectrode tech-nic. After administration of TFH 100 - 200 mg · L-1, the action potential duration of 50% repolarization, (APD50 ) was shortened both in cultured rat myocardial cells and in guinea pig papillary muscles. The slope of phase 4 of depolarization (SP4) in cultured rat myocardial cells was decreased and the contractile force (CF) in guinea pig papillary muscles was weakened. Arrhythmias evoked by strophantin G in guinea pig papillary muscles were suppressed by TFH 100 mg · L-1. These findings suggested that the influence of TFH on myocardial cells may be resulted mainly from its inhibition of Ca2+ influx and its interference with intracellular Ca2+ reservoir.更多还原