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T-2毒素对培养软骨细胞生长代谢的作用
Effect of T-2 Toxin on the growth and metabolism of cultural chondrocytes
【摘要】 报告了T-2毒素对培养软骨细胞生长代谢的作用。结果显示,在软骨细胞生长早期和旺盛时期,T-2毒素抑制细胞DNA合成,影响软骨细胞的分裂增殖,同时也影响到细胞的代谢功能,其毒性作用随T-2浓度升高细胞损伤加重。对于较成熟的软骨细胞,其毒性作用不明显。
【Abstract】 In this paper, the effects of T-2 toxin on the growth and metabolism of cultural chondrocytes were reported. The result showed that the T-2 toxin restrains the DNA synthesis, and affects the division and growth of chondrocytes at the early and exuberant stage of the growth, meanwhile,affects the function of metabolism; that the higher the concentration of T-2 toxinin in the media,the more damage to the chondrocytes; that the toxicity seemed not to affect mature chondrocytes.
【基金】 "八五"重点计划攻关课题
- 【文献出处】 中国地方病学杂志 ,CHINESE JOURANL OF CNDEMIOLOGY , 编辑部邮箱 ,1994年05期
- 【分类号】R684.102
- 【被引频次】20
- 【下载频次】96