【摘要】 灵芝浸膏给小鼠灌胃，每日1．0g／2．0g／kg，连续3d，末次给药后1h，用束缚水浸法造成应激性溃疡。结果表明，灵芝能显著降低溃疡的发生率及减少胃粘膜出血。灵芝拮抗乙酰胆碱对离体肠肌的收缩，IC50为8．5×11-4g／ml。灵芝抑制应激性溃疡的形成，可认为是其对外周副交感神经的阻断作用。更多还原

【Abstract】 Mice were pr.treat0d P0 with 0.4g/kg, 1.0g/kg, 2.0g/kg Lingzhi aqeous extract once dailY for 3daYs respectiv.lY. lh after the last d0se, they were kept under restraint plus water-imm-ersiou stress for 22h.Lingzhi 1.0g/kg, 2.0g/kg, an d at roping 0.04g/kg markedly dec reased ulc-er formation and hemorrhage incidences comparcd with control (P<0 .01 ). Lingzhi in differ-cnt doages could produced by acetylcholine. Its IC,, was found to be 8.5 x 10-’g/ml. Ulccr fo-rmation uudcr strcss condition is due to stimulation of the excessive central hypothalamus andParasymPathctic nervous system5 especially vaga1 ove racti vity p1ays au important rol e. T he results suggest that Lingzhi posscsses a blocking effects on peripheral pa ra-sympathetic nerv -ous syste m更多还原