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紫苏子油对小鼠学习记忆能力的影响

Effects of Fatty Oil of Acute Common Perilla (Perilla frutescens)on the Learning and Memory of Mice

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【作者】 周丹韩大庆王永奇

【Author】 Zhou Dan; Han Daqing, and Wang Yongqi ( Jilin Provincial College of Traditional Chinese Medicine and Materia Medica, Changchun)

【机构】 吉林省中医中药研究院中药研究所!长春130021

【摘要】 分别给予幼龄小鼠灌胃不同剂量的紫苏子油,连续15d,可减少小鼠跳台错误次数,能明显提高小鼠水迷路测验的正确百分率,缩短到达终点时间,并能促进小鼠脑内核酸及蛋白质的合成,调节小鼠脑内单胺类神经递质水平。结果提示紫苏子油能促进小鼠学习记忆功能并与小鼠脑内的核酸,蛋白质及单胺类神经递质含量有关。

【Abstract】 Different doses of fatty oil of Perilla frutescens var. arguta (Benth. ) Hand. -Mazz. (ig )to mice for i5 days can decrease errors in step-down test, improve percentage of accuracyand shorten the time to reach their goal in water maze experiments. lt also facilitate thesynthesis of RNA, DNA and proteins in brain and regulates the level of monoamine -like ne-urotransmitters. The above results indicated that fatty oil of P. frutescens var .arguta canimprove learning and memory in mice related to the symthesis of RNA, DNA, proteins andneurotransmitters in braiu.

【关键词】 紫苏子油学习记忆蛋白质单胺类递质
  • 【文献出处】 中草药 ,Chinese Traditional and Herbal Drugs , 编辑部邮箱 ,1994年05期
  • 【分类号】R285
  • 【被引频次】89
  • 【下载频次】343
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