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润喉宁抗病毒作用的研究
Study on Anti-virus Actions of Runhouning(Radix Rehmanniae,Rhizoma Belamcandae,etc)
【摘要】 润喉宁(由地黄、射干、乌梅、薄荷等组成)在0.0689g/ml的浓度时,能明显抑制流感病毒FM1株、单纯疱疹病毒Ⅰ型(HSV-1)和腺病毒A3所致的细胞病变(CPE)。免疫荧光试验显示,当其浓度为0.14g/ml和0.28g/ml时,均能抑制流感病毒FM1和HSV-1在Hep-2细胞上的增殖。以5,10,20g/kg·d剂量ig给予小鼠,对小鼠流感病毒性肺炎及鼠肺内流感病毒的增殖量、均有明显抑制作用。
【Abstract】 Runhouning,composed of Radix Rehmanniae,Rhizoma Belamcanndae, Fructus Mume,Herba Menthae,etc,can significantly inhibit the cytometaplasia(CPE)induced by FM1 strain of influenzal virus,I type of herpes simplex virus(HSV-1)and adenovirus A,at concentration of 0.0689g/ml.The immunofluorescent test showed that it can inhibit the proliferation of both FM1 strain of influenzal virus and I type of herpes simplex virus(HSV-1)on Hep-2 cells when it is at a concentration range(from 0.14g/ml to 0.28g/ml). It also has the strong inhibition on the influenzal viral pneumonia and the proliferation amount of intrapulmonic influenzal virus of mice following the.administration of perfusing stomach in mine (5,10,20g/kg/d).
【Key words】 Runhouning; influenzal virus; herpes simplex virus; immunofluorescent test;
- 【文献出处】 中成药 ,CHINESE TRADITIONAL PATENT MEDICINE , 编辑部邮箱 ,1994年06期
- 【分类号】R285.6
- 【被引频次】16
- 【下载频次】70